The origin of Charles V Palace (Palacio de Carlos V) was the need for a place that would include all the comforts of the time for the Emperor and his family, as the palaces, which were their summer residence, did not cover their needs.

The Emperor ordered the construction of the palace next to the Alhambra in order to enjoy its wonders. The architect in charge of the works was Pedro Machuca, an experienced architect in love with the Renaissance. The works started in 1527 and were totally finished in 1957. The construction went through several stages, the lack of financing resources, revolts that stopped the works, etc. The building was sometimes neglected to such an extent that the ceilings collapsed.